长期致力于病原微生物研究，被认为是微生物群体感应领域的奠基者之一、群体淬灭防治微生物病害新理论的创建者；近年来提出病原微生物致病力再编程的新理论，获得国际同行关注与重视。归国前任新加坡科技局分子与细胞生物学院教授；2011年回国后创建华南农业大学群体微生物研究中心并担任主任；国务院学位委员会第七届植物保护学科评议组成员，入选国家杰出青年科学基金(海外)、教育部长江学者讲座教授、国家高层次人才特聘专家等；曾获澳大利亚“博士后研究员奖”、新加坡“国家科学奖”等奖励。先后主持国家973项目、国家自然科学基金重点项目、国家自然科学基金区域创新联合基金项目、广东省重点领域研发计划、广州市科学研究计划重点项目等。发表SCI论文200余篇，包括Nature（2篇）、Nature Biotechnology、Nature Chemical Biology、Nature Communications、PNAS（8篇）等国际刊物文章，16篇论文受到Faculty1000等国际同行专家推荐/撰文介绍或遴选为种子文章；文章引用次数2.6万（Google Scholar)，h-index 76, i10-index 227；入选爱思唯尔中国高被引学者榜单。多次受邀在国际刊物发表综述文章，并应邀赴美国、英国、法国、芬兰、意大利、瑞士、加拿大、澳大利亚、印度、新加坡、日本、韩国等多个国家和地区作学术报告。

研究领域：

微生物群体感应系统、群体淬灭机制、病原-寄主跨界通讯

教育背景：

1989.04-1993.02 澳大利亚Adelaide大学植物保护系，博士

1982.09-1985.06 华南农业大学植物病理系，硕士

1982.02-1985.01 华南农业大学林学系，学士

工作经历：

1982.02 –1982.08 广东省林业勘察设计院助理工程师

1985.02 – 1989.02 华南农业大学植物病理系助教

1993.03 – 1997.05 澳大利亚昆士兰大学植物系博士后研究员

1997.06 – 1998.06 澳大利亚维省植物生物工程中心资深科学家/实验室主任

1998.06 – 2000.07   新加坡分子农业生物学院资深科学家/首席研究员

2000.08 – 2002.07   新加坡分子农业生物学院副教授/首席研究员

2002.08 – 2009.03   新加坡分子与细胞生物学院副教授/首席研究员

2006.09 – 2016.08 新加坡国立大学生物学系客座教授

2009.04 – 2011.10   新加坡分子与细胞生物学院教授/主任研究员

2011.11 – 2016.09   华南农业大学植物病理系教授

2016.10 –至今     华南农业大学群体微生物研究中心教授/主任

主要学术兼职和奖励荣誉：

1、学术兼职：先后兼任Journal of Microbiology and Biotechnology, Comparative and Integrative Biology,Science in China Serial C: Life Science,Molecular Plant-Microbe Interactions，Annual Review of Microbiology, Antibiotics, mLife等期刊编委

2、奖励荣誉：澳大利亚科研理事会（ARC）博士后研究员基金项目（1996）；国家杰出青年科学基金(海外)（2001）；新加坡国立大学卓越研究员奖（2002）；新加坡国家科学奖（2005）；教育部长江学者讲座教授（2006）；广东省领军人才特聘教授（2011）；国家高层次人才特聘专家（2012）；中国侨界贡献奖-创新团队（2016）；美国微生物学院院士（2017）；广州市荣誉市民（2018）；中国植物病理学会会士（2018）。

代表性论文：

Huang J, Zhou T, Zhou X, Xue Y, Zhao W, Liao L, Chang C, Zhang LH*, Xu Z*. Dural-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch inPseudomonas aeruginosa.Nature Commun2026, 17: 1926.

Liang Z, Liu H, He L, Chen Z, Gu W, Wu X, Chen Q, Wang X, Zhang LH*.Functionalcharacterisation of thequorum-sensingregulator ExpREcz inmodulation ofDickeya oryzaemotility andvirulence. Mol Plant Pathol 2026, 27: e70274.

WangX, LiG, ZouY, CaoH, LiaoL, ZhouX, ZhangLH*, Xu Z*.Anantibiotic-responsive regulator orchestrates chronic-to-acute virulence switch inPseudomonas aeruginosa. Nucleic Acids Res 2025, 53: gkaf471.

Gu W, Chen Y, Xie C, Chen Z, Gao H, Zhu Y, Zhang LH*, Liao L*. The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation ofDickeya oryzae motility. mBio 2025, 16: e0101625.

Zhou J, Hu M, Zhang LH*Dickeya diversity and pathogenic mechanisms. Annu Rev Microbiol 2024, 78: 621-642.

Wang H, Dong L, Wu W, Hu H, Zhang LH*, Liao L*. RdmA is a key regulator in autoinduction of DSF quorum quenching inPseudomonas nitroreducens HS-18. mBio2023，14: e0301022.

Zhou J, Ma H, Zhang LH*.Mechanisms ofvirulencereprogramming inbacterialpathogens.Annu Rev Microbiol 2023, 77: 561-581.

Wang H, Lin Q, Dong L, Wu W, Liang Z, Dong Z, Ye H, Liao L, Zhang LH.Abacterialisolatecapable ofquenchingbothdiffusiblesignalfactor andN-acylhomoserinelactone-familyquorumsensingsignalsshowsmuchenhancedbiocontrolpotencies. J Agric Food Chem. 2022, 70: 7716-7726.

Liu S, He F, Lin N, Chen Y, Liang Z, Liao L, Lv M, Chen Y, Chen S, Zhou J,Zhang LH*.Pseudomonas sp.ST4 produces variety of active compounds to interfere fungal sexual mating and hyphal growth. Microbial Biotech2020,13:107-117.

Wang J, Wang J,Zhang LH*. Immunological blocking of spermidine-mediated host-pathogen communication provides effective control againstPseudomonas aeruginosainfection. Microbiol Biotech2020,13: 87-96.

Chen, Y., Zhou, J., Lv, M., Liang, Z., Parsek, MR, Zhang LH. Systematicanalysis of c-di-GMPsignalingmechanisms andbiologicalfunctions inDickeya zeae EC1.mBio 2020, 11: e02993-20.

WangH, LiaoL, ChenS,ZhangLH*.A quorum quenching bacterial isolate contains multiple substrate-inducible genes encoding for degradation of diffusible signal factor.Appl Environ Microbiol2020,86: e02939-19.(F1000 recommended Good/New Finding).

Wang C, Ye F, Chang C, Liu X, Wang J, Wang JP, Yan XF, Fu Q, Zhou J, Chen S, Gao YG,Zhang LH*.Agrobacteria reprogram virulence gene expression by controlled release of host conjugated signals. PNAS2019,116: 22331-22340. (F1000 recommended Very good /New Finding /Interesting Hhypothesis /Good for Teaching)

Wang J, Wang J, Zhang LH. Immunological blocking of spermidine-mediated host-pathogen communication provides effective control againstPseudomonas aeruginosa infection. Microbiol Biotech2020,13: 87-96.

Dela Ahator S, Zhang LH. Smallismighty- chemicalcommunicationsystems inPseudomonasaeruginosa. Annual Review of Microbiology2019,73: 559-578.

Liu SY, Lin NQ, Chen YM, Liang ZB, Liao LS, Lv MF, Chen YF, Tang YX, He F, Chen SH, Zhou JN and Zhang LH. Biocontrol ofsugarcanesmutdisease byinterference offungalsexualmating andhyphalgrowthusing abacterialisolate. Front Microbiol2017,8: 778.

Liang Z, Huang L, He F, Zhou X,Shi Z, Zhou J, Chen Y, Lv M, Chen Y,ZhangLH*.A substrate-activatedeffluxpump DesABCconferszeamineresistance inDickeya zeae. mBio 2019, 10: e00713-19.

Wang C*, Liu X, Wang J, Zhou J, Cui Z,Zhang LH*.Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system inPseudomonas aeruginosa.Sci Rep2016,6: 30949.

Deng Y, Wu J, Yin W, Li  P, Zhou J, Chen S, He F, Cai J,Zhang LH*. Diffusible signal factor family signals provide a fitness advantage toXanthomonas campestrispv.campestris in interspecies competition.Environ Microbiol2016,18: 1534-1545.

Lee J, Zhang LH*.Thehierarchyquorumsensingnetwork inPseudomonas aeruginosa. Protein & Cell2015,6: 26-41.

Wang C, Ye F, Kumar V, Gao YG, Zhang LH*.BswR controls bacterial motility and biofilm formation inPseudomonas aeruginosathrough modulation of the small RNArsmZ.Nucleic Acids Research2014,42: 4563-4576.

Fan H, Dong Y, Wu D, Bowler MW, Zhang LH*, Song H*. QslA disrupts LasR dimerization in antiactivation of bacterial quorum sensing. PNAS2013,110: 20765-20770.

Lee J, Wu J, Deng Y, Wang J, Wang J, Wang LH, Chang C, Dong Y, Williams P, Zhang LH*.A cell-cell communication signal integrates quorum sensing and stress response. Nature Chem Biol2013,9: 339-343.

Wu D, Lim SC, Dong Y, Wu J, Tao F, Zhang LH*, Song H*. Structural basis of substrate binding specificity revealed by the crystal structures of polyamine receptors SpuD and SpuE fromPseudomonas aeruginosa. J Mol Biol 2012, 416: 697-712.

Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L*, Zhang LH*. Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric quanosine monophosphate turnover.PNAS2012,109: 15479-15484.

Deng Y, Wu J, Tao F, Zhang LH*Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria. Chem Rev2011,111: 160-173.

Tao F, He YW, Wu DH, Swarup S, Zhang LH*.The cyclic nucleotide  monophosphate domain ofXanthomonas campestris global regulator Clp defines a new class of c-di-GMP effector. J Bacteriol2010,192: 1020-1029. (F1000 recommended Good/New Finding)

He YW, Boon C, Zhou L, Zhang LH*.Co-regulation ofXanthomonas campestris virulence by quorum sensing and a novel two-component regulatory system RavS/RavR. Mol Microbiol2009,71: 1464-1476. (F1000 recommended Good/New Finding)

Boon C, Deng YY, Wang LH, He YW, Xu JL, Yang F, Pan SQ, Zhang LH*. A novel DSF-like signal fromBurkholderia cenocepaciainterferes withCandida albicansmorphological transition. ISME J 2008, 2: 27-36.(F1000must Read)

Goryachev AB, Toh DJ, Wee KB, Lee T, Zhang HB, Zhang LH. (2005) Transition to quorum sensing in anAgrobacterium population: a stochastic model. PLoS Comp Biol 2005, 1: e37. (F1000 recommendread)

Dong YH, Zhang XF, Xu JL, Zhang LH*.InsecticidalBacillus thuringiensis silencesErwinia carotovoravirulence by a new form of microbial antagonism – signal interference. Appl Environ Microbiol 2004,70: 954-960.(Featured inNature Reviews Microbiology2004, 2: 272)

WangLH, He YW, Gao YF, Wu JE, Dong YH, Wang RB, He CZ, Wang SX, Weng LX, Xu JL, Tay L, Fang RX, Zhang LH* (2004) A bacterial cell-cell communication signal with cross-kingdom structural analogs. Mol Microbiol 2004, 51: 903-912. (F1000 recommended Very Good /New Finding /Interesting Hypothesis)

Zhang LH.Quorum quenching and proactive host defense. Trends Plant Sci 2003,8: 238-244.

Zhang HB, Wang LH, Zhang LH*.Genetic control of quorum-sensing signal turnover inAgrobacterium tumefaciens.PNAS2002,99: 4638-4643.

Dong YH, Gusti AR, Zhang Q, Xu JL, Zhang LH*.Identification of quorum-quenchingN-acyl homoserine lactonases fromBacillusspecies. Appl. Environ Microbiol 2002, 68: 1754-1759. (F1000 recommended Very Good /New Finding)

Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH* (2001) Quenching quorum sensing-dependent bacterial infection by anN-acylhomoserine lactonase. Nature2001,411:813-817. (Featured inNature2001, 411:748-749;Nature Reviews Molecular Cell Biolology2001, 2: 488;Nature Biotechnology2001, 19: 735-736; F1000recommended Exceptional/New Finding/Technique Advance).

Dong YH, Xu JL, Li XZ, Zhang LH*.AiiA, an enzyme inactivates acyl homoserine-lactone quorum-sensing signal and attenuates the virulence ofErwinia carotovora.PNAS2000,97: 3526-3531. (Featured inNature 2001, 411:748-749;Nature Biotechology2001, 19: 735-736).

Zhang LH, Xu JL, Birch RG.Engineered detoxification confers resistance against a pathogenic bacterium. Nature Biotech 1999, 17: 1021-1024. (Featured inNature Biotechnology1999, 17: 958-959;Trends Plant Science2000, 5: 8)

Zhang LH*, Birch RG.The gene for albicidin detoxification fromPantoea dispersa encodes an esterase which attenuates pathogenicity ofXanthomonas albilineans to sugarcane.PNAS 1997, 94: 9984-9989.

Zhang LH, Murphy P, Kerr A, Tate M.Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones. Nature1993,362: 446-447. (Selected as a seminal paper for reprinting inAgrobacterium tumefacium - From Plant Pathology to Biotechnology)