研究领域：

长期从事分子微生物学与生物化学研究，研究方向包括（1）微生物CRISPR-Cas应用开发，（2）细菌致病性与耐药性机理研究，（3）细菌金属离子稳态调控机制研究等。

学习经历：

2010.9-2014.6：浙江大学，应用生物科学专业  学士

2014.9-2019.1：香港大学，分子微生物学和生物化学专业  博士

工作经历：

2019.2-2021.1：香港大学，博士后

2021.2-至今：华南农业大学，副研究员

社会兼职：

《Frontiers in Microbiology》《Journal of Visualized Experiments》客座编辑

发表论文：

[1] Lin Q, Wang H, Huang J, Liu Z, Chen Q, Yu G, Xu Z, Cheng P, Liang Z* and Zhang L*. Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa. Microbiology spectrum, 2022; e0064422.

[2] Xu Z, Park TJ and Cao H*. Advances in mining and expressing microbial biosynthetic gene clusters. Critical Reviews in Microbiology, 2022; DOI:10.1080/1040841X.2022.2036099

[3] Zhou T, Huang J, Liu Z, Lin Q, Xu Z* and Zhang L*. The two-component system FleS/FleR represses H1-T6SS via c-di-GMP signaling in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 2022; 88: e01655-21.

[4] Liang Z, Liu H, Xu Z and Zhang L*. First Report of Pectobacterium aroidearum Causing Soft Rot in Olecranon Honey Peach (Prunus persica L.) in China. Plant Disease, 2021; https://doi.org/10.1094/PDIS-10-21-2238-PDN

[5] Duan C, Cao H, Zhang L* and Xu Z*. Harnessing the CRISPR-Cas systems to combat antimicrobial resistance. Frontiers in Microbiology, 2021; 12: 716064.

[6] Zhou T, Huang J, Liu Z, Xu Z* and Zhang L*. Molecular Mechanisms Underlying the Regulation of Biofilm Formation and Swimming Motility by FleS/FleR in Pseudomonas aeruginosa. Frontiers in Microbiology, 2021; 12: 707711.

[7] Xu Z, Li Y, Cao H, Si M, Zhang G, Woo P, Yan A*. A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation. Nucleic Acids Research, 2021; 49: e94.

[8] Wang H, Wang M, Xu X, Gao P, Xu Z, Zhang Q, Li H, Yan A, Kao R and Sun H*. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance. Nature Communications, 2021; 12: 3331.

[9] Li Y#, Xu Z#, Han W#, Cao H#, Umarov R, Yan A, Fan M, Chen H, Duarte C, Li L, Ho P, Gao X*. HMD-ARG: Hierarchical Multi-task Deep learning for Annotating Antibiotic Resistance Genes, Microbiome, 2021; 9: 40.

[10] Xu Z, Li Y, Li M, Xiang H, Yan A*. Harnessing the type I CRISPR-Cas systems for genome editing in prokaryotes, Environmental Microbiology, 2021; 23: 542-558.

[11] Xu Z*, Li Y, Yan A*. Repurposing the native type I-F CRISPR-Cas system in P. aeruginosa for genome editing, STAR Protocols, 2020; 1: 100039.

[12] Xu Z#, Li M#, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo P, Xiang H*, Yan A*. Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa, Cell Reports, 2019; 29: 1707–1717.

[13] Xu Z, Wang P, Wang H, Yu ZH, Au-Yeung HY, Hirayama T, Sun H, Yan A*. Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli, Journal of Biological Chemistry, 2019; 294: 16978-16991.

[14] Wang H, Yan A, Liu Z, Yang X, Xu Z, Wang Y, Wang R, Koohi-Moghadama M, Hu L, Xia W, Tang H, Wang Y, Li H, Sun H. Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli, PLoS Biology, 2019; 17: e3000292.

[15] Cao H, Xia T#, Li Y#, Xu Z#, Lo Y, Bougouffa S, Bajic VB, Luo H, Woo P, Yan A*. Uncoupled quorum sensing modulates the interplay of virulence and resistance in a multidrug-resistant clinical Pseudomonas aeruginosa isolate belonging to the MLST550 clonal complex, Antimicrobial Agents and Chemotherapy, 2019; 63: e01944-18.

[16] Wang Z#, Sun J#, Tian M#, Xu Z, Liu Y, Fu J, Yan A*, Liu X*. Proteomic analysis of FNR-regulated anaerobiosis in Salmonella Typhimurium, Journal of The American Society for Mass Spectrometry, 2019; 30: 1001-1012.

[17] Cao H*, Lai Y, Bougouffa S, Xu Z, Yan A*. Comparative genome and transcriptome analysis reveals distinctive surface characteristics and unique physiological potentials in Pseudomonas aeruginosa ATCC 27853, BMC Genomics, 2017; 18: 459.

[18] Heshiki Y, Dissanayake T, Zheng T, Kang K, Ni Y, Xu Z, Sarkar C, Woo P, Chow K. C. Chow, Baker D, Yan A, Webster C, Panagiotou G*, Li J*. Toward a Metagenomic Understanding on the Bacterial Composition and Resistome in Hong Kong Banknotes, Frontiers in Microbiology, 2017; 8: 632.

[19] Lai Y, Xu Z, Yan A*. A novel regulatory circuit to control indole biosynthesis protects Escherichia coli from nitrosative damages during the anaerobic respiration of nitrate, Environmental Microbiology, 2017; 19: 598-610.

[20] Xu Z, Yan A*. Multidrug efflux systems in microaerobic and anaerobic bacteria, Antibiotics 2015; 4: 379-396.

授权专利：

[1] Yan A, Xu Z. A transferable type I-F CRISPR-Cas system for genome editing in P. aeruginosa, PCT/CN2021/128715

科研项目：

[1] 国家自然科学基金青年科学基金项目, 锌胁迫抑制铜绿假单胞菌群体感应系统的作用机制研究, 2022.01 - 2024.12, 主持

[2] 广东省自然科学基金面上项目, 铜绿假单胞菌中双组分系统FleS/FleR对III型分泌系统的调控机制研究, 2022.01 - 2024.12, 主持

[3] 广州市基础与应用基础研究项目, 铜绿假单胞菌中双组分系统FleS/FleR调控生物膜形成的分子机理研究, 2022.04 - 2024.03, 主持

[4] 华南农业大学新农村发展研究院农村科技特派员服务团队项目, 2021.07 - 2023.07, 参与

[5] Health and Medicine Research Fund (香港医疗卫生研究基金HMRF), Establishing a Pseudomonas aeruginosa-Caenorhabditis elegans embryogenesis model for assessment of the P. aeruginosa virulence and identification of novel virulence factors, 2020.07 - 2023.06, 参与