Eduction & Experience:
2008 – 2011 Ph.D., Zhejiang University, Hangzhou, China
1999 – 2002 Master, South China Agricultural University, Guangzhou, China
1995 – 1999 Bachelor, Hunan Agricultural University, Changsha, China
Professional Experience:
2019 – Present South China Agricultural University, Guangzhou, China, Professor & Principle Investigator
2014 – 2018 South China Agricultural University, Guangzhou, China, Associate Professor & Principle Investigator
2011– 2014 Institute of Molecular and Cell Biology, A-STAR, Singapore, Research Fellow
2002 – 2008 Institute of Molecular and Cell Biology, A-STAR, Singapore, Assistant Research Officer & Research Officer
Research Interests:
The research in Dr. Chang’s laboratory is focused on the pathogensis of the fungal pathogen Sporisorium scitamineum which causes sugarcane smut disease.The life cycle of S. scitamineum is divided into three stages based on cell morphology and lifestyle, the yeast cell-like haploid sporidium, the dikaryotic hypha and the teliospore. Yeast-like sporidium is haploid cell, non-pathogenic and grows by budding. Two compatible sporidia develop infectious dikaryotic hyphae through sexual mating. Dikaryotic hypha grows along with sugarcane bud meristem and eventually forms the appressorium on the inner scales of the young buds. Chang’s laboratory is principally concerned with two aspects of this fungus: I. How the opposite mating types sporidia recognize each other and initiate sexual mating to develop dikaryotic hypha. II. The biochemistry and molecular biology of environmental sensing and response of the fungus. All of these phenomena are of importance in pathogenesis. Chang’s lab welcomes diverse types of research collaborations and is interested in recruiting ambitious and highly motivated postdoctoral research associates and postgraduate students to join team.
Selected publications and patents(#: Co-author; *: Corresponding author):
1. Kaihuai Li #, Jinxing Liao #, Ming Wei, Shanxu Qiu, Wu Weiyin, Yancun Zhao, Haihong Wang, Qiongguang Liu, Fengquan Liu * and Changqing Chang * (2022) The Xanthomonas citri reverse fitness deficiency by activating a novel β-glucosidase under low osmostress. Frontiers in Microbiology. doi: 10.3389/fmicb.2022.887967.
2. Enping Cai#, Shuquan Sun#, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang*, and Zide Jiang* (2021) Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1.Journal of Fungi. 7(8) 610. doi: 10.3390/jof7080610.
3. Enping Cai, Lingyu Li, Yizhen Deng, Shuquan Sun, Huan Jia, Rongrong Wu, Lianhui Zhang, Zide Jiang*, Changqing Chang*(2021) MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress.Environmental Microbiology. 23(6):3306-3317.
4. 蔡恩平, 梅丹, 张小萌, 孙贤, 李玲玉, 吴熔熔, 邓懿祯, 姜子德*, 常长青* (2020) 甘蔗鞭黑粉菌原生质体转化DNA双片段的基因敲除方法的建立。菌物学报22,39(12):2314-2327。
5. JinXing Liao#, KaiHuai Li#, JinPei Wang, JiaRu Deng, QiongGuang Liu, ChangQing Chang* (2019) RNA-seq analysis provides insights into the cold stress responses of Xanthomonas citri pv. citri. BMC genomics. 20 (1):807.
6. Chao Wang#, Fuzhou Ye#, Changqing Chang#, Xiaoling Liu, Jianhe Wang, Jinpei Wang, Xinfu Yan, Qinqin Fu, Jiannuan Zhou, Shaohua Chen, Yonggui Gao*, and Lianhui Zhang* (2019) Agrobacteria reprogram virulence gene expression by controlled release of host conjugated signals.PNAS. 116(44):22331-22340.（F1000评论）。
7. Changqing Chang#*, Cai Enping#, Deng Yizhen, Dan Mei, Shanxu Qiu, Baoshan Chen, Lian-Hui Zhang, Zide Jiang* (2019) cAMP/PKA Signaling Pathway Regulates Redox homeostasis essential for Sporisorium scitamineum Mating/Filamentation and Virulence. Environmental Microbiology. (3):959-971.
8. Shuquan Sun, Yizhen Deng, Enping Cai, Meixin Yan, Lingyu Li, Baoshan Chen, Changqing Chang*, Zide Jiang* (2019) The Farnesyltransferase β-Subunit Ram1 Regulates Sporisorium scitamineum Mating, Pathogenicity and Cell Wall Integrity. Frontiers in Microbiology. 8(10):976.doi: 10.3389/fmicb.2019.00976.
9. Jianuan Zhou#, Haibao Zhang#, Mingfa Lv, Yufan Chen, Lisheng Liao, Yingying Cheng, Shiyin Liu, Shaohua Chen, Fei He, Zining Cui, Zide Jiang, Changqing Chang*, Lianhui Zhang* (2016) SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol. Plant Pathology.17 (9) :1398-1408.
10. Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David Lane, Jinrong Peng* and ChenJun* (2015) p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Research. 25(3):351-69.
11. Ou Zhao#, Yin Le#, Changqing Chang#, Jinrong Peng*, Jun Chen* (2014) Protein Interaction Between p53 and Δ113p53 Is Required for the Anti-Apoptotic Function of Δ113p53. Journal of Genetics and Genomics. 41 (2):53-62.
12. Jasmine Lee, Je’en Wu, Yinyue Deng, Jing Wang, Chao Wang, Jianhe Wang, Changqing Chang, Yihu Dong, Paul Williams, Lianhui Zhang* (2013) A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology. 9(5):339-43. (F1000评论)。
13. Yinyue Deng#*, Nadine Schmid#, Chao Wang, Jianhe Wang, Gabriella Pessi, Donghui Wu, Jasmine Lee, Claudio Aguilar, Christian H. Ahrens, Changqing Chang, Haiwei Song, Leo Eber*, Zhang LH* (2012) Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover. PNAS. 109(38):15479-84.
14. Jingang Liu#, Lu Gong#, Chang Changqing#, Cong Liu, Jinrong Peng*, Jun Chen* (2012) Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish. Journal of Genetics and Genomics. 39(9):489-02.
15. Changqing Chang, Minjie Hu, Zhihui Zhu, Li Jan Lo, Jun Chen*, Jinrong Peng* (2011) liver-enriched gene
16. Jun Chen, Sok Meng Ng#, Changqing Chang#, Zhenhai Zhang, Jean Christophe Bourdon, Lane David P. Lane*, Jinrong Peng* (2009) p53 isoform ∆113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Dev. 23:278-290 (F1000评论)。
17. Fuquan Liu, Weimin Ni, Megan E.Griffith, Zhiyuan Huang, Changqing Chang, Wen Peng, Hong Ma*, Daoxin Xie* (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. The Plant Cell.16: 5-20.
18. 常长青，邓嘉茹，姜子德，廖金星，陈少华，王金佩，蔡恩平。柑橘溃疡病菌产生小分子作为噻唑类杀菌剂增效剂在病害防治中的应用。专利号：ZL 201711152617.5。
19. 常长青，廖金星，邓嘉茹，徐领会，刘冉淋，章婉贤。AHL分子作为化学农药杀菌增效剂在柑橘溃疡病防治中的应用。专利号：ZL 201810334632.X。
20. 常长青，仇善旭，王雨婷，蔡恩平，沈荣晨，吴熔熔，李玲玉。一种纳米复合材料g-C3N4/Ni及其制备方法与应用。专利号：ZL 201811547445.6。